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This results in a lower ability to promote receptor internalization compared with endogenous GLP-1, so it allows to have an increased GLP-1R expression on the cell surface, which translates in more robust insulinotropic properties, possibly explaining the enhanced insulin secretion (in both diabetic and not diabetic human islets), induced by TZP (19) by approximately 25% more than the one induced by only one of the two agents
S., Brndsted, L., Kankam, M., et al
For example, if you were taking medication daily, switching to weekly medication may be challenging, as you may forget to administer your next dosage on the scheduled day due to the gap of one week
Reassess: Every few months, check in with your pharmacist or doctor to ensure the combination is still serving your health goals
AI can enable the design of novel drugs binding to the GLP-1 receptor and predicting their binding ability with the receptor
