GLP-1RA drugs, widely used to manage diabetes and obesity, are known to slow gastrointestinal motility, potentially affecting the quality of bowel cleansing necessary for accurate colonoscopy screenings
Sugar-sweetened beverages, including sodas and drinks made with high-fructose corn syrup, should be eliminated
Alcohol should be limited, as its high in empty calories and can intensify GI side effects
The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges ( in vivo may be lower, exposure continues for a prolonged period as the half-life of DEAQ is 10 to 12 days ( The relative contribution of GSTP1 to GSH-conjugation of both QIs was highest at GSH-depleted conditions, while in absolute quantities a higher GSTP1-dependent increase of GSH conjugate formation was seen without BSO pre-treatment ( Figure 5 )
Armstrong likes to order a 12-piece grilled chicken nugget meal and stretch it across a few meals (nuggets make great salad toppings, she notes)