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The relationship between thyroid function and metabolic health is bidirectional and complexthyroid hormones influence glucose metabolism and insulin sensitivity, while metabolic dysfunction can affect thyroid hormone conversion and action at the cellular level

PLoS ONE 14(1): e0210389

Therefore, the combined use of GLP-1 RAs with therapies targeting intrahepatic pathways, such as thyroid hormone receptor (THR-) agonists, fibroblast growth factor-21 (FGF21) analogues, and peroxisome proliferator-activated receptor (PPAR) agonists, presents a promising approach for MASH treatment

So long as the brand-name options remain pricy, theres incentive for 503As to create these slightly changed versions

doi: 10.1001/jamainternmed.2013.2720 221 KnapenLMvan DalemJKeulemansYCvan ErpNPBazelierMTDe BruinMLet al