N-acetyl-L-cysteine (NAC), low-molecular-weight dextran sulfate (LMW-DS), fondaparinux, and bivalirudin inhibit the coagulation system, while PMX53, ripasudil, gadolinium chloride (GdCl 3 ), and glycine inhibit innate immune system, thereby alleviating hepatocyte clearance
doi: 10.1016/j.foodcont.2020.107228 91
Macrophage-inducible C-type lectin (Mincle) can activate KCs through recognizing a damaged hepatocyte releasing endogenous ligand, named spliceosome-associated protein 130 (SAP130), to exacerbate APAP hepatotoxicity
Its use should be avoided unless specifically recommended by a healthcare provider after a careful risk-benefit assessment
The identified classes in plants include DHARs, Elongation factor 1 gamma (EF1G), Lambda (GSTL), Phi (GSTF), Tau (GSTU), Tetrachlorohydroquinone dehalogenase (TCHQD), Theta (GSTT), and Zeta (GSTZ) (Mohsenzadeh et al., 2011)