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The RT prototypes without the carboxylic acid groups, such as RT-NH 2 and TQG-CN, are fairly hydrophobic and cannot distribute in the nucleus, which is a hallmark of protein binding for fluorescent probes (Fig

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It could be the difference between observing a therapeutic effect, no effect, or even a toxic effect

Nitrosative stress is also present, as illustrated by markers of nitrosative stress such as increased NOS and NO (182, 297), peroxynitrite (182, 297), elevated NF- production (182), and nitrate after exercise (182, 297)