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Saxenda (liralutide) : Saxenda (liraglutide) is an injectable medication prescribed for chronic weight management in adults with obesity or overweight individuals with at least one weight-related condition
Patent CN105154498a example 10 discloses Arg34GLP-1 (9-37) main peptide chain is coupled with side chain with carboxyl protected by tert-butyl (tBu), then coupled with Boc-His (Boc) -Aib-OH dipeptide in presence of HATU and TEA, reaction time is as long as 14 days, freeze-drying time is as long as 16 hours after HPLC purification by post-treatment, which is not good for industrial production, and Boc has no strong absorption of Trt in ultraviolet, which is not good for reaction monitoring, and Boc has no good stability of Trt, which results in generation of racemic impurities
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Delayed gastric transit Worsening nausea and vomiting Increased risk of malnutrition 11
Growth hormone directly influences sleep architecture through modulation of slow-wave sleep, and GH secretion peaks during the first 90 minutes of deep sleep
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