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We also adjusted for a claims based frailty index30 to address potential confounding by frailty and for a claims based combined comorbidity score.31 Comorbidities and drug use were assessed in the 365 days before and including the cohort entry date and based on international classification of diseases (version 9 and 10) diagnosis and procedure codes, and generic drug names, respectively

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Opioid withdrawal symptoms happen because your body has adapted to the presence of opioids

L., Sachs, G