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Of these, eight CYP enzymes participate in cholesterol metabolism (CYP7A1, CYP27A1, CYP46A1, CYP11A1, CYP51A1, CYP39A1, CYP8B1 and CYP7B1), but CYP51A1 is the only one involved in the de novo synthesis of cholesterol
Furthermore, the concomitant rate of auto-oxidation of doxorubicin within the cell is assumed to be equal to that of the OCR experimental data used to parameterise the model
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