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In the US, for example, manufacturers have faced multidistrict litigation over alleged links to pancreatic cancer, with plaintiffs claiming inadequate warnings and defective design

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It also showed greater average weight loss with Tirzepatide at 3, 6, and 12 months

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And in the context of GH biology, overshooting carries consequences: IGF-1 excess has associations with insulin resistance, fluid retention, and in some populations, oncological risk