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As a secondary end-point, a direct comparison with liraglutide (up to 1.8 mg) was made

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The SUSTAIN clinical trial program, which evaluated semaglutide in over 8,000 patients with type 2 diabetes, consistently showed improvements in HbA1c, fasting plasma glucose, and body weightall indirect indicators of improved insulin sensitivity

A prespecified analysis of the SELECT trial examined the relationship between changes in adiposity measures (body weight and waist circumference) and cardiovascular outcomes among 17,604 patients with obesity or overweight and established cardiovascular disease but without diabetes.[1] The analysis revealed that cardiovascular outcomes were similar among semaglutide-treated patients who did or did not lose at least 5% of their baseline body weight, and that semaglutide consistently reduced major adverse cardiovascular events across the full spectrum of baseline body mass index values

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