These carefully conducted studies clearly showed that prolonged procedure (for 12 weeks) of a daily LC and CHO ingestion induced a raise of skeletal muscle TC levels [5,6,7], affecting exercise metabolism [5], improving performance [5] and energy expenditure [6], without altering body composition [6]
this was shown to protect against Ang II-induced injury in the heart and aorta, potentially associated with inhibition of NOX4 expression and preservation of mitochondrial integrity, reduced the protein levels of NADPH oxidase 4 (NOX4) and TGF1 and expression of monocyte chemoattractant protein 1, and attenuated the proliferation of myofibroblasts culminating in reduced aortic wall thickness [81]
The animals activity levels rose in the form of moving around more and improved their performance on memory challenges
Since many people on GLP-1 medications also manage cholesterol with statins, the double depletion can produce significant fatigue and muscle weakness
This rise in popularity is understandable