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As a saturated monobasic weak acid containing four carbon atoms, butyrate primarily exists as dissociated butyrate anions in physiological systems

Souto and Antonello Santini, "The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements", Molecules

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J Anal Pharm Res

To prolong plasma half-life and improve drug delivery, butyrate and sorafenib were co-encapsulated within antibody-functionalized mPEG-PLGA-PLL nanoparticles, which significantly reduced sorafenib-induced liver injury and suppressed hepatocellular carcinoma progression [121]