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Originally developed as a glucagon-like peptide-1 (GLP-1) receptor agonist for managing type 2 diabetes, its sought-after weight-reducing effects have garnered widespread attention
The key insulinotropic actions of GLP-1 via the class B1 G-protein-coupled receptor (GPCR) are exerted by cyclic adenosine monophosphate (cAMP) formation, which, in conjunction with increased Ca 2+ levels, promotes exocytosis of insulin-containing vesicles [39]
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They can determine whether an antihistamine or other treatment is required
Effects of thirty-times chewing per bite on secretion of glucagon-like peptide-1 in healthy volunteers and type 2 diabetic patients
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