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Consequently, plants have developed a sophisticated network of defense systems to protect themselves from pathogen incursions and the development of diseases ( The GSH itself is created from amino acids, including glutamate, L-cysteine, and glycine, through two ATP-dependent enzymatic reactions mediated by -glutamylcysteine synthetase (-ECS or also known as GSH1) and GSH synthetase (GS or also named GSH2) ( Figure 1 )

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Quellen Wu, Fang, et al., Glutathione Metabolism and Its Implications for Health, J Nutr, vol

(49) have confirmed that in vitro treatment with UA can reduce the expression levels of fibrosis markers including vimentin, discoidin domain receptor tyrosine kinase 2, tensin and Alpha-smooth muscle actin in myocardial tissues, and inhibit the transition of cardiac fibroblasts to a fibrotic state through nuclear factor erythroid 2-related factor 2 signaling pathway