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406,407 Detailed analysis of astrocytic morphology using genetic reports (either ALDH1L1-eGFP reporter mice or viral transfection with astrocyte-targeted mCherry) revealed significant decrease of astrocytic complexity and shrinkage of astrocytic territorial domains in prefrontal cortex (Fig

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in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis (44)