hashimoto's and semaglutide Can someone with Hashimoto’s take the new class of Semaglutide, Mounjaro, WeGovy, or Ozempic? There are so many misconceptions about who can can’t take these medications. Hashimoto’s is not a Semaglutide and Thyroid Health: What

Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1, NEJM 2021) Jastreboff AM et al

2) Glycaemic control endpoints in type 2 diabetes research protocols Retatrutide has also been evaluated in a phase 2 type 2 diabetes trial (The Lancet) that measured: HbA1c change at 24 weeks body weight change at 24 weeks adverse events and discontinuations within the protocol The paper reports dose dependent improvements in both glycaemic and weight outcomes in the trial setting, which is why retatrutide is often discussed as a next generation metabolic peptide for integrated glycaemic and weight endpoints in published clinical research

M.GreenoughM

found that in human pancreatic ductal adenocarcinoma (PDAC) cell lines, treatment with erastin induced STING1 translocation from the ER to mitochondria and triggered mitochondrial fusion by binding to MFN1/2, which led to increased mtROS levels without triggering PINK1/Parkin-independent mitophagy, eventually causing ferroptosis [117]

The SELECT cardiovascular outcomes trial actually demonstrated cardiovascular benefit rather than harm, which was reassuring