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For the cell experiments, all cell samples were randomly coded by an independent third party, and experimenters conducted treatments and measurements without knowledge of the specific group assignments
DORA: 48-week weight and metabolic changes in black women with HIV, in a phase IIIb switch study from dolutegravir- or efavirenz- to doravirine-based first-line antiretroviral therapy
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Despite low CNS penetration, some studies report detectable levels in the brain, supporting its potential for systemic biological effects without significant accumulation (Jzwiak et al
Another potent oral PARP1/2 inhibitor, niraparib (MK4827) binds to the active site of PARP enzymes, and studies indicate that Niraparib can restore NAD + levels and improve mitochondrial function 165,166
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