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Pharmacological management of glycaemic control in people with type 2 diabetes

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3.2 Necroptosis of tubular epithelial cell in DKD Transcriptomic and single-nucleus RNA sequencing analyses have demonstrated significant enrichment and perturbations of the necroptosis pathway in diabetic kidney tissues, highlighting its core role in driving tubulointerstitial injury (27, 135)

In addition, the babies were more often born with structural abnormalities in different organs, tissues, and parts of the skeleton: the heart, blood vessels, kidney, liver, cranial bones, vertebra, sternebra, and ribs