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Numerous tissues, including the brain, contain the nonapeptide, which is composed of nine amino acids

[PMID: 16538523] PubMed record related to this compound for laboratory literature review

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Those with advanced stages of Adrenal Fatigue need to be very cautious because they usually respond quite differently

Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)