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Glutathione peroxidase activity is neuroprotective in models of Huntington's disease
Besides classical targets, FoxOs also regulate noncanonical E3 ligases such as MUSA1, FBXO31, SMART (FBXO21), and Itch, with FoxO3 as the dominant factor (Li et al., 2022)
Insulin-like growth factor-1 and lipid metabolism IGF-1 promotes preadipocyte differentiation [181], however, as preadipocytes differentiate, they stop expressing IGF-1Rs, delegating such functions now to insulin receptors, which increase in number significantly
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