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Ozempic and Stomach Paralysis (Gastroparesis) Research suggests that Ozempic and other GLP-1 receptor agonists may substantially increase a persons risk of developing gastroparesis or stomach paralysis
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GLP-1R agonists may also exert their neuroprotective action increasing level and activity of brain-derived neurotrophic factor, regulating calcium homeostasis, promoting glycolysis, and reducing vascular damage (Du et al., 2022)
These are open research questions, and the combination data come largely from preclinical and short-term studies that have not been validated in large human trials
