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Lipid improvements typically become apparent within 12-20 weeks of initiating GLP-1 receptor agonist therapy, paralleling the weight loss trajectory

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The establishment of 1919 GBM cells with overexpression of wildtype PSPH and PSPH V116I was confirmed by enhanced expression of PSPH by immunoblot and consecutive upregulation of ser/gly pathway enzyme SHMT2, most pronounced in PSPH V116I cells (Fig

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