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clusterProfiler: an R package for comparing biological themes among gene clusters
Although the factors that promote this dysregulation are poorly understood in PD, recent data suggest that increased -synuclein levels can reduce autophagic flux by decreasing the autophagosomal membrane-associated protein LC3, resulting in further accumulation of -synuclein and cytotoxicity (Figure 3A) (Lei et al., 2019)
Our Inflammation and Longevity Medicine hub and article on Inflammation, Brain Health, and Mental Wellbeing explain why inflammatory burden belongs in the cognitive-health conversation
Szymaski M, Wandtke T, Wasilow K, Andryszczyk M, Janicki R, Domaracki P
The NIH Office of Dietary Supplements, citing Institute of Medicine recommendations, advises that it is advisable for those older than 50 years to meet their RDA mainly by consuming foods fortified with vitamin B12 or a supplement containing vitamin B12. This recommendation reflects the fact that 10 to 30% of older adults lose the ability to efficiently absorb naturally occurring B12 from food
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