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Nature Cell Biology, 11 (11), 1305-1314

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While it has been postulated that these two actions are inextricably linked more recent data shows they can indeed be divorced which opens the opportunity for tailored pharmacology that provide food intake reduction without the adverse events typically associated with GLP-1R agonism

470 Another randomized controlled trial included 8,343 patients with ischemic (low blood flow-related) stroke or TIA unrelated to a cardioembolism (a blood clot that formed in the heart and travelled to the brain)