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Total weight loss by week 12 typically ranges from 5% to 8% of starting body weight, depending on the medication and dose
This intentional slowing of gastric emptying has raised questions about whether GLP-1 therapy causes gastroparesis, a serious condition where the stomach cannot empty properly
For example, the p53 mutants p53 R 237 H and p53 R 175 H promote sensitivity to ferroptosis-like cell death, most likely through the combination of p53 mutants with NRF2 and through the suppression of the NRF2-dependent transactivation of SLC7A11 together with other antioxidant genes that oppose ferroptosis (Sasaki et al., 2002