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The Pernicious Anaemia Society notes this is well recognised but not fully understood

For those using B12 for general wellness, the effects can be more graduala steady feeling of being more energized and focused over time

Jeon H, Min J, Kim DK, Seo H, Kim S, Kim YS

UK obesity guidance including NICE CG189 (Obesity: identification, assessment and management) and NICE PH53 (Weight management: lifestyle services for overweight or obese adults) does not recommend vitamin B12 supplementation as a weight management intervention

People with these variants might need more careful monitoring and possibly different supplements