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Elevation of CAT activity was also reported in rat hepatoma steatotic cells as compared to their respective controls (Vecchione et al

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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)

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These breakdown products also activate neuro-inflammatory pathways, particularly the Toll-Like receptor 4 (TLR-4) activated NFB pathway ( These intricate cascades eventuate in the disruption of the bloodbrain barrier, microcirculatory dysfunction, and the manifestation of cerebral edema