Dose Range: 100300 mcg daily with gradual titration
If this occurs, discontinue use and consult a healthcare professional
The cell surface annotation rate was calculated using a subset of proteins expected to be exposed on the cell surface, which are annotated in UniProt 55 , Human Protein Atlas 56 and Gene Ontology (GO) cellular component 57,58 terms including cell membrane, cell surface, secreted (secretory granule, synaptic vesicle), endosomes (early, late, recycling, membrane), lysosome, plasma membrane (basal, apical, lateral, external side, raft), extracellular regions (space, matrix, vesicle, exosome), immunological synapse, cilium, intercellular bridge, membrane raft, junctions (adherens, bicellular tight, anchoring, cellcell), presynaptic membrane, early endosome, basement membrane, exocyst, ruffle membrane and focal adhesion (Supplementary Table 4)
Supplement use should complement, not replace, clinical assessment of antioxidant status and underlying health conditions
Lipoxin A4 ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes