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Decreased CBF observed in the early stages of AD, non-demented PD patients, ALS cases before cognitive decline, and in normally appearing white matter of MS patients without cognitive impairments, implies that CBF reduction may serve as an early biomarker, preceding neurodegenerative changes
A.da RochaL
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Handling and Stability Risks Improper handling exposure to light, heat, repeated freeze-thaw cycles, or strongly alkaline conditions can degrade the peptide or disrupt copper coordination, producing experimental variability that is sometimes mistaken for biological inconsistency
Stack the two gaps together and the picture for the conventional protocol is unflattering: approximately one-fifteenth of the studied dose, delivered by a route that animal data suggest requires several-fold more peptide, targeting a compound whose dose-response may not be monotonic anyway
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