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Archived from the original on 19 May 2012

Prediction of pediatric dose of tirzepatide from the reference adult dose using physiologically based pharmacokinetic modelling

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GLP-1 was also demonstrated to increase cAMP levels in adult rat cardiac myocytes (307), but in that study GLP-1 decreased contraction amplitude as opposed to isoproterenol, which augmented amplitude and, again unlike isoproterenol, GLP-1 did not bring about any intracellular calcium transients, but did cause a modest intracellular acidification

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