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Mayo Clinics ENDO 2025 study of 120 postmenopausal women found tirzepatide plus HRT produced 17% weight loss vs 14% alone over 18 months, with 45% of HRT users hitting 20%+ loss vs 18% of non-users (see our tirzepatide vs semaglutide analysis)
The picture in men, where PT-141 is used off-label, is broadly similar for those effects, but two points are specific to men
Alkabbani W, Suissa K, Gu KD, Cromer SJ, Paik JM, Bykov K, et al
Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity
However, certain factors such as aging, poor diet, and environmental pollutants can deplete glutathione levels, leading to an increased risk of eye problems
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