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Degeneration of the lower motor neurons in the brainstem and spinal cord and the upper motor neurons in the motor cortex results in gradual denervation of voluntary muscles, leading to disruption of neural networks through a complex set of mechanisms eventually culminating in motor and non-motor symptoms (Table 2
Key inspection and enforcement metrics at a glance The table below consolidates the headline metrics from this piece into a single reference worth bookmarking ahead of your next compliance briefing or leadership update
