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The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication
Immune disorders such as Graves disease and lupus
Experimental observations and model development We developed a mechanistic model focused on the regulation of intracellular lipolysis and the release of fatty acids and glycerol from the adipose tissue
Drug Delivery Translational Research 9, 625630
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