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Retinoids are the only topical ingredient class with FDA approval for actual structural wrinkle reduction, not just cosmetic appearance

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Loren Pickart, and it can naturally be found in human saliva, plasma, and urine.12 (The GHK in skin care products is synthetic.) Experts originally believed GHK was a liver cell growth factor, but as research advanced, they learned that the peptide could alter far more cells than just those in the liver