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Whereas much of the current attention surrounding GLP-1 RAs, or glucagon-like peptide-1 receptor agonists, has been focused on their unexpected and potent effect on weight loss, one important aspect of this class of drugs should not be overlooked: GLP-1 RAs have been shown to reduce the risk of heart attack, stroke, and other major adverse cardiovascular events (MACE) in patients with type 2 diabetes who have or are at high risk for atherosclerosis

Eli Lilly noted that discontinuation rates were highly correlated with baseline BMI, with participants who had lower baseline BMI more likely to discontinue due to excessive weight loss