Side effect rates at 12mg are meaningfully higher than at 8mg: Nausea: 43.2% of participants (vs 38.1% at 9mg) Diarrhea: 33.1% (vs 34.7% at 9mg) Constipation: 25.0% (vs 21.8% at 9mg) Vomiting: 20.9% (vs 20.4% at 9mg) The decision between 8mg, 10mg, and 12mg as a maintenance dose should be made based on individual response
These advantages are prompting healthcare systems to integrate GLP-1s into first-line or second-line therapy guidelines
These estimations will then be confirmed in vitro with carefully designed HLA binding studies based on known ligands which have been modified to contain UAA in HLA anchoring positions
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