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In some people, the gut doesn't make enough natural GLP-1, or the brain isn't sensitive to it
Physiologically, IR is defined as a state of reduced responsiveness to high physiological levels of insulin in insulin-targeted tissues
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The article says anyone with pre-existing depression, anxiety, or an eating disorder should discuss GLP-1 use with both their prescriber and their mental health provider, since the medication may amplify disordered eating behaviors or trigger mood dysregulation in vulnerable populations
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