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Understanding both the strength and limitations of this evidence base helps contextualize treatment decisions
Oral supplements: can work for mild deficiency and maintenance in people who absorb B12 normally, but tend to take longer and are less reliable when absorption is impaired
In vitro research models use that clinical literature as a translational reference point, with cell-based GHRH receptor binding assays and pituitary somatotroph cell models providing the upstream mechanistic data
How long after starting vitamin B12 will I feel better
At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range
