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Clinical evidence: key trials and outcomes The kidney-protective potential of SGLT2 inhibitors was first identified in cardiovascular outcome trials, including Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus PatientsRemoving Excess Glucose (EMPA-REG OUTCOME) [36], Canagliflozin Cardiovascular Assessment Study (CANVAS) [37], and Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARETIMI 58) [38]

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Acute illness, severe vomiting, or signs of dehydration

These drugs have surged in popularity in recent years, often marketed as effective and relatively safe options for metabolic conditions

doi: 10.1002/brb3.1505 238 PanagakiTGenglerSHolscherC