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doi: 10.1016/j.numecd.2014.10.007 16 WolfeF.ClauwD

Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus

However, recent research indicates a concerning trend: approximately 50% of individuals prescribed these second-line therapies discontinue their usage within a year