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Intramuscular injection, by contrast, deposits peptide 1540mm deep (depending on needle length and injection site), requiring the compound to enter venous return, circulate systemically, and then diffuse back out of dermal capillaries to reach fibroblasts

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Two theories are most prominent- the amyloid beta (A) and the tau phosphorylation hypothesis

doi: 10.1016/0966-842x(96)10057-3 232 Rajili-StojanoviMSmidtHde VosWM