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Those who used Victoza alone experienced a decrease in BMD

46 Drug-Drug Interactions: Saxagliptin is a strong CYP3A4 inhibitor, so its labeling recommends limiting saxagliptin to 2.5 mg daily in patients taking other strong CYP3A4 inhibitors, such as ketoconazole, based on the risk of increased saxagliptin levels

Circulation (2011) 124(21):233849

Ibuprofen belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs)

By comparison, orlistat (Xenical) produced approximately 3-4 kg more weight loss than placebo over 12 weeks in its pivotal trials, and GLP-1 agonists produce 8-15 kg more than placebo