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Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

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The achievement rate of the target BP increased from 25.4% after treatment to 33.3% after combination therapy ( p = 0.003)

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However, as our understanding of cell signaling and regulatory pathways has developed, so has the involvement of GSH homeostasis in many other key processes, including regulation of cell proliferation and apoptosis and post-transcriptional modification of proteins through S-glutathionylation