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The change was computed using a two-sided t-test at a significance level of 5%
The combination of tirzepatide with niacinamide is not made by the original manufacturer (Eli Lilly)
Other GLP-1 receptor agonists such as liraglutide 3mg (Saxenda) or tirzepatide (Mounjaro, per NICE TA1026) may be considered according to local commissioning arrangements and NICE guidance
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The four sub-amounts sum back to the total: 1,667 + 333 + 333 + 333 = 2,666 mcg, rounding to ~2,667 mcg
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