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Patients healing from cosmetic procedures

More elegantly, the peptide itself can be redesigned for stability unnatural amino acids (like Aib), cyclization, D-amino acid substitutions, and PEGylation all make the molecule harder for proteases to cleave and can extend half-life

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A companion mechanistic paper, Chang et al., Molecules 2014, found that the peptide up-regulated growth-hormone-receptor expression in tendon fibroblasts at both mRNA and protein levels, potentially sensitising these cells to growth hormone during repair