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This process is driven by the inactivation of glutathione peroxidase 4 (GPX4) and the pathological accumulation of lipid hydroperoxides (LPOs) within cellular membranes (Stockwell et al., 2017

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Subsequent increases happen at four-week intervals, moving to 1mg, then 1.7mg, and potentially up to 2.4mg per week for weight management

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