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It was unexpected that the concentrations of MDL29,951 that had the strongest effects on cAMP inhibition (i.e., 100-300 nM MDL29,951) had modest effects on regulation of GLP-1 secretion, and the concentrations of MDL29,951 that yielded the most robust inhibition of GLP-1 secretion (i.e., 25 M MDL29,951) had no significant effect on cAMP regulation
The relevance to humans is unclear, as humans have fewer thyroid C-cells than rodents
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