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Senescence induction causes a marked upregulation of p16INK4a expression, leading to cell cycle arrest in the G1 phase and thereby preserving the senescent phenotype by blocking the cyclin-dependent kinases CDK4 and CDK6, which stops the retinoblastoma protein (pRb) from being phosphorylated (Sharpless and Sherr 2015)

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The dose of your acenocoumarol (Sintrom) might need to be changed

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Key tips for clinicians include: Ask about gallbladder history before starting therapy Monitor for right upper quadrant pain or nausea after meals Educate patients on when to seek medical evaluation For most, the benefits of GLP1 therapy outweigh the risks, but patient awareness is critical for timely diagnosis and care