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1,407 adults with BMI 30 kg/m and without diabetes were included in the trial

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12 Bulk RNA sequencing of brainstem and nucleus accumbens after treatment with GLP-1MK-801

Targeting inflammasome activation, inhibiting caspase-1, employing anti-inflammatory agents, and modulating the gut microbiota and bile acid metabolism represent promising avenues for developing novel treatments for this common and potentially life-threatening condition