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Running them together is expected to make these effects more frequent and more intense during the co-escalation phase (roughly weeks 9-20 in the staggered protocol)

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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

Benefit 10: Recovery from Surgery and General Anesthesia Patients recovering from surgery or anesthesia often face high oxidative stress in the brain and the body

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